The past few decades have seen a lot of peptide research directed to investigating the ability of cell penetrating peptides to pass through the cell membrane barrier of the Trans cellular or intracellular for the purposes of delivering cargo such as imaging agents, proteins, molecular weight drugs, and colloidal carriers amongst others. The CPPs ability to pass across biological plasma membranes, is highly admired since it can lead to increased drug bioavailability. There have been several attempts at trying to extract related structural information, which would enhance the uptake process of transport peptides.
Bioavailability of hydrophilic substances, have always been of the major setbacks in the development of new therapeutic agents. It is a known fact that drugs that attach themselves to the intracellular targets must go through the lipid layer membrane that surrounds the cells, before they are able to unleash their effectiveness. But fortunately, there is relatively new research targeting this problem, and this aims to overcome the obstacle through the introduction of novel transport peptides. These peptides have attracted the attention of many researchers, and there is currently a lot of work going on around the study.
A good number of researchers are considering the delivery of many therapeutic molecules by using various cell penetration peptides, as well as their ability to be used in a wide range of applications. These peptides are known to have a net positive charge, and they are amphipathic in nature, though they can also have different characteristics, which offer them the ability to go through the plasma membranes of mammalian cells. CPPs are sometimes referred to as Protein transduction domains.
Though many studies are still underway, the results obtained so far are pleasing, and it seems as if another major breakthrough is just about to be achieved regarding these types of peptides.